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XELJANZ/XELJANZ XR (tofacitinib) is a prescription medicine called a Janus kinase (JAK) inhibitor used to treat:

  • Adults with moderately to severely active rheumatoid arthritis in whom methotrexate did not work well.
  • Adults with active psoriatic arthritis in whom methotrexate or other similar medicines called nonbiologic disease-modifying antirheumatic drugs (DMARDs) did not work well.

XELJANZ is also used to treat:

  • Adults with moderately to severely active ulcerative colitis.

It is not known if XELJANZ/XELJANZ XR is safe and effective in children or in people with hepatitis B or C.

XELJANZ/XELJANZ XR is not recommended for people with severe liver problems.

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